Drug-induced parkinsonism in schizophrenic patients: motor response and psychiatric changes after acute challenge with L-Dopa and apomorphine.
| Autores | Merello M, Starkstein S, Petracca G, Cataneo EA, Manes F, Leiguarda R. |
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| Año | 1996 |
| Journal | Merello M, Starkstein S, Petracca G, Cataneo EA, Manes F, Leiguarda R. |
| Volumen | 19(5): 439-443 |
| Abstract | Acute single-dose response of drug-induced parkinsonism (DIP) to L-Dopa and apomorphine challenge was evaluated in a double-blind crossover study in 12 schizophrenic patients. There were two noteworthy negative findings. First, neither L-Dopa nor apomorphine produced significant improvements in DIP and second, no changes (neither improvement nor worsening) were found in patients’ psychiatric status. Findings suggest that, for a stimulation dose reaching almost 90% of the responsive dose for idiopathic Parkinson’s disease, no significant changes may reasonably be expected in the parkinsonism of schizophrenic patients treated with neuroleptic drugs. |
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