Affective symptoms are a common occurrence in patients with epilepsy, both in the form of comorbidity with depressive and bipolar syndromes, as well as symptoms associated with the neurological picture itself. The concept of affective temperaments constitutes an element of interest to understand the predisposition of certain patients whose personality characteristics confer a higher risk of developing comorbid affective pathology. Consequently, this line of research aims to reveal the presence of temperamental affective traits in patients with epilepsy and establish the association between these traits and the presence of affective comorbidity, affective symptomatology, quality of life, perception of disease, pharmacological adherence, and satisfaction with antiepileptic treatment.