| AUTORES | Del C Valdés Hernández M, Abu-Hussain J, Qiu X, Priller J, Parra Rodríguez M, Pino M, Báez S, Ibáñez A. |
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| 2019 | |
| JOURNAL | Brain and Behavior |
| VOLUMEN | DOI: 10.1002/brb3.1343 |
| ABSTRACT | Introduction: The volume of the striatal structures has been associated with disease progression in individuals with Huntington’s disease (HD) from North America, Europe, and Australia. However, it is not known whether the gray matter (GM) volume in the striatum is also sensitive in differentiating vulnerability from disease manifestation in HD families from a South‐American region known to have high incidence of the disease. In addition, the association of enlarged brain perivascular spaces (PVS) with cognitive, behavioral, and motor symptoms of HD is unknown. Materials and Methods: We have analyzed neuroimaging indicators of global atrophy, PVS burden, and GM tissue volume in the basal ganglia and thalami, in relation to behavioral, motor, and cognitive scores, in 15 HD patients with overt disease manifestation and 14 first‐degree relatives not genetically tested, which represent a vulnerable group, from the region of Magdalena, Colombia. |
| En este trabajo mostramos que una combinación de imágenes cerebrales y pruebas neurocognitivas permiten distinguir entre pacientes que presentan la enfermedad de Huntington y los que tienen una vulnerabilidad pero no han desarrollado aún la enfermedad. |